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In addition, the antioxidant activity may play a role in inducing antinociception.
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The medicinal bark of this plant, which is native to Mexico and the Pacific coastline, was highly revered by indigenous peoples as acleanser of thebody and mind. Spanish explorers, fascinated by its healing properties, referred to this healing botanical as Cascara sagrada - which meanssacred bark. Inmodern times, its power to purge the body of impurities sparked the interest of the pharmaceutical industry - Cascara sagrada became themost common activeingredient in over-the-counter laxatives until it was banned by the FDA in May 2002. Cascara sagrada is used today by traditional healers,naturopaths, andhealth-minded individuals to cleanse the colon of toxic matter, and research indicates that Cascara sagrada not only increases vitality butalso protectsagainst colon cancer.
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Numerous scientific studies had evaluated the anticancer properties of Solanum (nightshade) species - in particular S. nigrum (blacknightshade), butalso S. mammosum (five-fingered eggplant), S. lyratum, S. dulcamara (bittersweet nightshade, Amara dulcis), and others. Note that severalnightshade speciesare highly toxic.
Rabdosia rubescens (whole plant) is a Chinese herb that is sometimes used in Traditional Chinese Medicine as treatment for cancer of theesophagus. Severalscientific studies haveassociated the active components of R. rubescens and cancer treatment. 
Antibacterial activity of the plant extract has also been reported.
A very significant amount of scientific research has been done in the investigation of anticancer properties of various plants - howevermuch work stillneeds to be done.
With the above said, on to our list of over 60 herbs and plants for which anticancer properties have been reported / claimed. This page has officially turned into a mammoth tome and we have done our best to cite all references. I hope this information is ofbenefit to you. Let's work togetherto fight against this tragic disease. Suggestions are welcomed; please see the foot of the page for contact information.
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ANALOGUES AND EVALUATION OP ANTICANCER ACTIVITY A Thesis submitted in part fulfilment of the requirements ...
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The resin contains up to 15% volatile oil; the remaining materials are resins and acids. The active biological properties of copaiba resin are attributed to a group of phytochemicals called (over 50% of the resin may be sesquiterpenes), , and . These chemicals include caryophyllene, calamenene, and copalic, coipaiferic, copaiferolic, hardwickic, and kaurenoic acids. Several of these chemicals are novel ones found only in copaiba. Copaiba resin is the highest known natural source of caryophyllene, comprising up to 480,000 parts per million. Caryophyllene is a well known plant chemical which has been documented strong anti-inflammatory effects (among other actions).
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Copaiba's traditional uses as an antiseptic for sore throat, upper respiratory and urinary tract infections can be explained partly by the resin's antibacterial properties documented in the 1960s and 1970s. Researchers again confirmed (in 2000 and 2002) that the resin as a whole (and, particularly, two of its diterpenes-copalic acid and kaurenic acid) demonstrated significant antimicrobial activity against gram-positive bacteria. One of copaiba's other chemicals, kaurenoic acid, has also demonstrated selective antibacterial activity against Gram-positive bacteria in other recent studies.
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Another recent area of research on copaiba resin has focused on its anticancerous and antitumor properties. Researchers in Tokyo isolated six chemicals (clerodane diterpenes) in the oleoresin of copaiba in 1994 and tested them against carcinomas in mice to determine their antitumor activity. One particular compound, called kolavenol, was twice as effective at increasing the lifespan in mice with carcinomas (by 98%) as the standard chemotherapy drug, 5-Fluorouacil (5-FU). The natural resin also increased lifespan by 82% - which was still higher than 5-FU (which increased lifespan by 46%). Interestingly, the tests provided better anti-tumor effects than in previous test-tube studies. The Spanish team of researchers that documented copaiba's antimicrobial effects in 2002 also tested for antitumor effects. These scientists reported that another phytochemical in the resin, methlyl copalate, had activity against human lung carcinoma, human colon carcinoma, human melanoma, and mouse lymphoid neoplasm cell lines. Brazilian researchers reported in 2002 that one of copaiba's active chemicals, kaurenoic acid, also inhibited the growth of human leukemic cells by 95%, and human breast and colon cancer cells by 45% in vitro. Kaurenoic acid can comprise as much as 1.4% of the natural copaiba oleoresin.
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• Study of an hydroalcoholic leaf extract in ovalalbumin-induced asthmatic rat model showed anti-asthmatic activity suppressing airway inflammation and airway hyperactivity.
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