Call us toll-free

Synthesis and Application of Glycopeptide and Glycoprotein Mimetics.

Living Radical Polymerization as a Tool for the Synthesis of Polymer-Protein/Peptide Bioconjugates.

Approximate price

Pages:

275 Words

$19,50

Synthesis of 5-Methylene-1,3-oxazolidin-2-ones

The spin crossover temperature of iron(III) complexes that are functionalized with alkyl-urea tails in solutions can be adjusted. By imposing very slight structural modifications in the number of methylene recognition sites in a position remote from the functional unit, i.e. the SCO active iron(III) centre, the transition temperature T1/2 is modulated in a predictable manner.

Part 1: The Synthesis of (S)-2-Methylhexanoic Acid
Photo provided by Flickr

We have investigated cis-aminoindanol-derived bis(oxazoline)-metal-catalyzed asymmetric reactions. The C2-symmetric chiral bis(oxazoline) ligands have now been developed as privileged ligands for a variety of asymmetric transformations. In an effort to improve Phe-Box-Cu(II)-catalyzed Diels-Alder reactions, we speculated that the cis-aminoindanol-derived bis(oxazoline) may well serve as a conformationally constrained alternative to the Phe-Box ligand. In this context, we first prepared aminoindanol-derived bis(oxazoline) ligands by condensation of the imidate salt with optically active aminoindanol. We have prepared a variety of metal-bis(oxazoline) complexes as catalysts for asymmetric Diels-Alder and hetero Diels-Alder reactions. As shown, Cu(II)-catalyzed reactions with acryloyl-N-oxazolidinone proceeded with excellent endo/exo selectivity as well as endo-enantioselectivity (up to 99% ee), in contrast to Phe-Box-Cu(II)-catalyzed reactions (30% ee).

New Synthesis of Chiral Oxazolidin-2-ones

Stereoselective Synthesis and Antibacterial Activity of a New 2-Oxazolidinone Derivative
Photo provided by Flickr

B., Synthesis of azide-alkyne fragments for click' chemical applications; formation of oligomers from orthogonally protected trialkylsilyl-propargyl azides and propargyl alcohols.

In summary, we have synthesized a class of novel and efficient bis(trifluoromethyl)phosphine-oxazolines as π-acceptor ligands which have shown good to excellent regio- and enantioselectivity for the Pd-catalyzed asymmetric allylic alkylation reaction of monosubstituted allyl carbonates. Further studies on the synthesis of 1-[bis(perfluoroalkyl)phosphine]-1’-oxazolinylferrocene ligands and their applications in asymmetric catalysis are ongoing in our lab.

S., Ethyl 2-(4-phenyl-1-1,2,3-triazol-1-yl)acetate.

"Click Labeling" with 2-[18F]Fluoroethylazide for Positron Emission Tomography.
Photo provided by Flickr

Inspired by the tautomeric relationship of imidazole and N-heterocyclic carbenes, we have been intrigued about the implications of such carbenes in metalloenzymes. Enzymes are the machinery of all biological transformations, and provide inspiration for designing artificial catalysts. New insights into the mode of action of enzymes is therefore instrumental for developing more competent synthetic catalysts as well as for better understanding natural systems. In collaboration with F. Paradisi (U Nottingham), we have begun to explore carbene binding to metalloenzymes. We have been focusing on blue copper proteins such as azurin and specific mutants of azurin to investigate the possibility of carbene bonding to the copper center, and to evaluate the effect that such bonding entails. While azurin is predominantly involved in electron transfer processes through reversible copper(II) reduction and oxidation, other blue copper proteins are catalytically active in redox transformations of substrates. Hence, these enzymes provide an attractive probe to explore the relevance of carbene bonding on the catalytic performance of the enzyme.

A class of novel, easily accessible and air-stable 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands has been synthesized from ferrocene. It became apparent that these ligands can be used in the regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates in a highly efficient manner. Excellent regio- and enantioselectivity could be obtained for a wide range of substrates.

Synthesis and Application of Phosphorus Dendrimer Immobilized Azabis(oxazolines).
Photo provided by Flickr
Order now
  • Synthesis of 1--Glycosylthiomethyl-1,2,3-triazoles.

    Synthesis of α-hydroxyacetophenone derivatives and ethyl spiro-3,3-(ethylenedioxy)-2-hydroxyindoline carboxylates

  • The synthesis of 2-oxazoline rings is well established ..

    X-ray study of (S,S)-di-μ-chlorobis-{2-[2-(4-tert-butyl)oxazolinyl]phenyl-C,N}dipalladium(II)

  • Major classes of oxazoline based ligand include: Bis ..

    Syntheses of Hemoprotein Models that can be Covalently Attached onto Electrode Surfaces by Click Chemistry.

Order now

Modular synthesis of chiral pentadentate bis(oxazoline) ligands

This way, a great variety of pentadentate bis(oxazoline) ligands in diastereo- and enantiomerically pure form become readily available, which are useful for the construction of helical metal complexes with predetermined chirality.

Synthesis of a bis(oxazoline) ..

A series of eight novel bis(oxazoline) ligands incorporating -disubstitution on one of the oxazoline rings were prepared from ()-valine. These ligands are designed as a cost-effective alternative to similar ligands possessing an oxazolinyl C(5)--butyl group derived from expensive ()--leucine. Four of the ligands possess a C(4)--dimethyl group and four a C(4)--diphenyl group adjacent to the C(5)-isopropyl substituent. Zinc complexes of ligands 11ah, along with non-C(4)--disubstituted analogues 1ag, were effective in the Friedel–Crafts alkylation of both indole (up to 74% ee) and 2-methoxyfuran (up to 95% ee) with a series of nitroalkenes. Three of the ligands (11ac), an iron dichloride complex of ligand 11d and two zinc dichloride complexes, were characterized by X-ray crystallography, one with ligand 11d and the second a bis--butyl-substituted -methylamine ligand. A direct comparison of the latter structures clearly illustrates the -dimethyl effect.

Improved Synthesis of Aza-bis(oxazoline) Ligands - …

This way, a great variety of pentadentate bis(oxazoline) ligands in diastereo- and enantiomerically pure form become readily available, which are useful for the construction of helical metal complexes with predetermined chirality.">

2,5-dimethyl pyrazine, 123-32-0 - The Good Scents Company

The spin crossover temperature of iron(III) complexes that are functionalized with alkyl-urea tails in solutions can be adjusted. By imposing very slight structural modifications in the number of methylene recognition sites in a position remote from the functional unit, i.e. the SCO active iron(III) centre, the transition temperature T1/2 is modulated in a predictable manner.

Polymers of 2-oxazoline are regarded ..

A straightforward synthesis of chiral aza-bis(oxazoline) (Azabox) ligands from commercially available amino alcohols is described. The new protocol allows access to previously reported Azabox ligands in considerably improved yields but also to new derivatives, including non-2-symmetrical ones.

Order now
  • Kim

    "I have always been impressed by the quick turnaround and your thoroughness. Easily the most professional essay writing service on the web."

  • Paul

    "Your assistance and the first class service is much appreciated. My essay reads so well and without your help I'm sure I would have been marked down again on grammar and syntax."

  • Ellen

    "Thanks again for your excellent work with my assignments. No doubts you're true experts at what you do and very approachable."

  • Joyce

    "Very professional, cheap and friendly service. Thanks for writing two important essays for me, I wouldn't have written it myself because of the tight deadline."

  • Albert

    "Thanks for your cautious eye, attention to detail and overall superb service. Thanks to you, now I am confident that I can submit my term paper on time."

  • Mary

    "Thank you for the GREAT work you have done. Just wanted to tell that I'm very happy with my essay and will get back with more assignments soon."

Ready to tackle your homework?

Place an order