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1-Phenethyl-4-piperidone 98% | Sigma-Aldrich

Studies in Piperidone Chemistry. i. a Synthesis of 5-Homopiperazinones - j Org Chem, 1949, 14(4), 530 - Jo01156a005

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Synthesis of piperidines - Organic Chemistry Portal

Three series of heteroaromatic analogs (twenty seven compounds) with monoketone linkers have been synthesized and evaluated for their antimicrobial activity against six microbial strains. Among them, 3,5-dibenzylidene-1-(3,5-dichloro-2-hydroxyphenylsulfonyl)piperidin-4-one 5e showed best antifungal activity against Aspergillus niger and Aspergillus fumigatus. Structural elucidation of the synthesized compounds was determined on the basis of various spectroscopic methods.

to provide the corresponding trans-2-substituted-4-halopiperidines or cis-2-substituted-4 ..

Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Phase I clinical trials have shown that curcumin is safe even at high doses (12 g/day) in humans but exhibit poor bioavailability. Major reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. To improve the bioavailability of curcumin, numerous approaches have been undertaken. These approaches involve, first, the use of adjuvant like piperine that interferes with glucuronidation; second, the use of liposomal curcumin; third, curcumin nanoparticles; fourth, the use of curcumin phospholipid complex; and fifth, the use of structural analogues of curcumin (e.g., EF-24). The latter has been reported to have a rapid absorption with a peak plasma half-life. Despite the lower bioavailability, therapeutic efficacy of curcumin against various human diseases, including cancer, cardiovascular diseases, diabetes, arthritis, neurological diseases and Crohnʼs disease, has been documented. Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.

N-Phenethyl-4-piperidinone - TAJ PHARMACEUTICALS …

Christie Morrill.; Neelakandha S. Mani. Synthesis of 4-Arylpiperidines from 1-Benzyl-4-piperidone:? Application of the Shapiro Reaction and Alkenylsilane Cross-Coupling. Org. Lett. 2007, 9 (8), 1505-1508.

Christie Morrill.; Neelakandha S. Mani. Synthesis of 4-Arylpiperidines from 1-Benzyl-4-piperidone:? Application of the Shapiro Reaction and Alkenylsilane Cross-Coupling. Org. Lett. 2007, 9 (8), 1505-1508.Chunmei Gao.; Yuyang Jiang.; Chunyan Tan.; Xuyu Zu.; Huachen Liu.; Derong Cao. Synthesis and potent antileukemic activities of 10-benzyl-9(10H)-acridinones. Bioorganic & Medicinal Chemistry. 2008, 16 (18), 8670-8675.

Synthesis of 4-piperidone Based Curcuminoids with …

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