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2,4,6-Trinitrotoluene may causetoxic hepatitis.

2,4,6-Trinitrotoluene undergoes both oxidative and reductive metabolismin animals.

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Overall evaluation 2,4,6-Trinitrotoluene is.

5.4 Other relevant data In humans, absorption of 2,4,6-trinitrotoluene both through theskin and the gastrointestinal route had been demonstrated.

Testicular atrophy occurs in rats following exposure to 2,4,6-trinitrotoluene.

Industrially, TNT is synthesized in a three-step process. First, is with a mixture of and to produce mono-nitrotoluene or MNT. The MNT is separated and then renitrated to or DNT. In the final step, the DNT is nitrated to trinitrotoluene or TNT using an mixture of nitric acid and . Nitric acid is consumed by the manufacturing process, but the diluted sulfuric acid can be reconcentrated and reused. Subsequent to nitration, TNT is stabilized by a process called sulphitation, where the crude TNT is treated with aqueous sodium sulfite solution in order to remove less stable isomers of TNT and other undesired reaction products. The rinse water from sulphitation is known as and is a significant pollutant and waste product of TNT manufacture.

TNT (Trinitrotoluene) is an similar to (based on ).

2,4,6-Trinitrotoluene is mutagenic in bacteria with and withouta metabolic activation system.

TNT is poisonous, and contact can cause skin irritation, causing the skin to turn a bright yellow-orange color. During the , munition workers who handled the chemical found that their skin turned bright yellow, which resulted in their acquiring the nickname "canary girls" or simply "canaries." People exposed to TNT over a prolonged period tend to experience and abnormal functions. and liver effects, enlargement and other harmful effects on the have also been found in animals that ingested or breathed trinitrotoluene. There is evidence that TNT adversely affects male , and TNT is listed as a possible human . Consumption of TNT produces red through the presence of breakdown products and not blood as sometimes believed.

In the laboratory, 2,4,6-trinitrotoluene is produced by a two step process. A nitrating mixture of concentrated nitric and sulfuric acids is used to nitrate toluene to a mixture of mono- and di-nitrotoluene isomers, with cooling to maintain careful temperature control. The nitrated toluenes are separated, washed with dilute to remove oxides of nitrogen, and then carefully nitrated with a mixture of and sulfuric acid. Towards the end of the nitration, the mixture is heated on a steam bath. The trinitrotoluene is separated, washed with a dilute solution of and then from alcohol.

Biological Degradation of 2,4,6-Trinitrotoluene

5.5 Evaluation There is  in humans for the carcinogenicityof 2,4,6-trinitrotoluene.

Exposures to 2,4,6-trinitrotolueneboth through inhalation and skin absorption can occur during itsproduction, during munitions manufacturing and loading, and duringblasting operations.

2,4,6-Trinitrotoluene has been detected inwastewater, surface and groundwater, and in soils and sedimentsnear plants manufacturing 2,4,6-trinitrotoluene and explosives.

There is  in experimental animals forthe carcinogenicity of 2,4,6-trinitrotoluene.
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  • Synthesis of 2,4,6-TNT from DNT.

    In workers exposed to 2,4,6-trinitrotoluene, increased bacterialmutagenic activity was found in the urine.

  • Chemistry - Trinitrotoluene (TNT)

    Page 88 Synthesis of benzannelated five-membered heteroaromatic compounds from 2,4,6-trinitrotoluene Maxim A

  • 2,4,6-trinitrotoluene - Memidex dictionary/thesaurus

    Although 2,4,6-trinitrotoluene was negative in mammals in vivo for unscheduled DNA synthesis in the liver ..

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Improved Synthesis of 3, 5-Diamino-2, 4, 6-Trinitrotoluene [Alan P

5.3 Animal carcinogenicity data No adequate study on the carcinogenicity of 2,4,6-trinitrotoluenein experimental animals was available to the Working Group.

2,4,6-TRINITROTOLUENE supplier | CasNO.118-96-7

In humans exposed to 2,4,6-trinitrotoluene, mainly dinitroaminotoluenesand also diaminonitrotoluenes, probably mainly as conjugates,as well as unchanged 2,4,6-trinitrotoluene were found in the urine.

2,4,6-Trinitrotoluene | C7H5N3O6 | 680186 | 118-96-7

In humans, exposure to 2,4,6-trinitrotoluene has been found tocause haematological disorders, including aplastic anaemia, haematolyticanaemia and methaemoglobinaemia.

2,4,5-Trinitrotoluene - Synchem

5.2 Human carcinogenicity data One ecological study was available that noted an association betweenleukaemia and residence in an area contaminated with 2,4,6-trinitrotoluene.

Trinitrotoluene - The Full Wiki

Although 2,4,6-trinitrotoluene was negative in mammals for unscheduled DNA synthesis in the liver and micronuclei inductionin bone marrow, the urine of rats is mutagenic after intraperitonealinjection of 2,4,6-trinitrotoluene.

2,4,6-Trinitrotoluene (TNT) is one of the most common explosives

Trinitrotoluene (pronounced ; abbreviated TNT), or more specifically, 2,4,6-trinitrotoluene, is a with the formula C6H2(NO2)3CH3. This yellow-coloured solid is sometimes used as a in chemical synthesis, but it is best known as a useful with convenient handling properties. The explosive yield of TNT is considered to be the of and other . In chemistry, TNT is used to generate .

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