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Bachelor of Pharmacy - AIMST University

(2014) Synthesis of Derivatives from Lawsone, Carvacrol, 1-Hydroxy Pyrazole and Their Biological Activities

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Molecules | October 2017 - Browse Articles

The C-3 substituted phenylazo derivatives of lawsone (2-hydroxy-l,4 p-naphthoquinone, III) were synthesized and characterized. The X-ray crystal structure was determined for the ligand 3-(3′-methyl phenylazo) lawsone. The copper complexes of these derivatives were found to possess 1:2 metal stoichiometry and square planar geometries with intermolecular stackings, resulting in antiferromagnetic exchange interactions. The in vitro activity of all the synthesized compounds was examined against human breast cancer cell-line, MCF-7, which revealed enhanced activities for the metal complexes, the highest activity being observed for the copper compound of 3-(3′-methyl phenylazo) lawsone.

studies including those about the chemistry of lawsone, the synthesis of its derivatives…

The synthesis of several xanthenes based on the 1,3-dicarbonyl scaffolds lawsone and coumarin was developed using tandem three-component reactions involving the reagents -hydroxybenzaldehyde, as bifunctional reagent, and an appropriate thiol. These reactions generated two series of - and -naphthoxanthenes that are structurally related to α- and β-pyranaphthoquinones and one series of coumarin-xanthene derivatives.

This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.

Molecules, an international, peer-reviewed Open Access journal.

Synthesis of Tetracyclic Phenazine Derivatives by Reactions of Lawsone with Diamines

"Abstract: The C-3 substituted phenylazo derivatives of lawsone (2-hydroxy-l,4 p-naphthoquinone, IIl) were synthesized and characterized. The X-ray crystal structure was determined for the ligand 3-(3’-methyl phenylazo)lawsone. The copper complexes of these derivatives were found to possess 1:2 metal stoichiometry and square planar geometries with intermolecular stackings, resulting in antiferromagnetic exchange interactions. The in vitro activity of all the synthesized compounds was examined against human breast cancer cell-line, MCF-7, which revealed enhanced activities for the metal complexes, the highest activity being observed for the copper compound of 3-(3’-methyl phenylazo) lawsone. Quinonoidal ligands when used as therapeutic agents can exercise their cytotoxic action by various mechanisms which include redox cycling, arylation, intercalation, induction of DNA strand breaks, generation of free radicals and alkylation via quinone methide formation ’2. The ability of 1,4 naphthoquinone to produce ’oxidative stress ’ by redox cycling and to act

With our growing interest in synthesis of biologically active aminonaphthoquinone derivatives from aliphatic/aromatic amines, the present investigation deals with the reactions between 2-hydroxy-1,4-naphthoquinone (lawsone) and derivatives of aminophenol.

In the past it was a common constituent of many medications

A series of eight substituted bis-2-hydroxy-1,4-naphthoquinone derivatives was synthesized through lawsone condensation with …

Their applications include labeling of small synthetic molecules and large biomolecules such as proteins, antibodies and nucleotides in DNA studies [4] .Aminophenol is an amphoteric molecule and a reducing agent.

Their applications include labeling of small synthetic molecules and large biomolecules such as proteins, antibodies and nucleotides in DNA studies [4] .Aminophenol is an amphoteric molecule and a reducing agent.

Starting from 2-hydroxy-1,4-naphthoquinone (lawsone), we synthesized eight new 6H-dibenzo[b,h]xanthene derivatives selectively under solvent-free conditions.
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  • Lawsone derivatives Publications and Abstracts | …

    naphthoquinones: biological properties and synthesis of lawsone and derivatives — a structured review

  • Lawsone Derivatives II. - Journal of Pharmaceutical Sciences

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    Quinone - Wikipedia

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