we report herein the synthesis of chalcone and its conversion to ..
06/11/2007 · Synthesis and biological activity of heterocycles from chalcone
and biological activity of heterocycles
It has been observed that combination of biologically active moieties in to one molecule and synthesizing newer moieties have been the methods of research. Based on these observations, during the present investigation newer chalcone derivatives were synthesized by coupling suitably modified 1,2,4-Triazoles nucleus and evaluated them for in vitro antimicrobial and antitubercular activities.
Many heterocyclic compounds are biosynthesized by plants and animals and are biologically active. Some heterocycles are fundamental to life, such as haem derivatives in blood and the chlorophylls are essential for photosynthesis. Similarly, the paired bases found in RNA and DNA are heterocycles, as are the sugars that in combination with phosphates provide the backbones and determine the topology of these nucleic acids. The biological properties of heterocycles in general make them one of the prime interests of the pharmaceutical and biotechnology industries.
Synthesis and biological activity of ..
Need for the study: The chemistry of heterocyclic compounds is the field in the organic chemistry which is being explored continuously. The importance of 1,2,4-triazole derivatives lies in the field that, these derivatives represent one of the most biologically active classes of compounds, possessing a wide range of therapeutic properties 5-6. Chalcones constitute an important family of substances belonging to flavonoids, a large group of natural and synthetic products with interesting physicochemical properties, biological activity and structural characteristics.
ABSTRACT: The literature survey on 1,2,4-Triazoles and chalcone derivatives revealed that they are endowed with wide variety of biological activities. During the present investigation newer series of chalcone derivatives S-4-(isonicotinamido)-5-(phenoxymethyl) - 4H-1,2,4 triazole-3-yl-3(-4-chlorophenyl) propanethioate (7a-7f) were synthesized by coupling suitably modified 1,2,4-Triazole nucleus with appropriate aryl aldehydes. The structures of the newly synthesized compounds were established by FTIR, 1HNMR and Mass spectral analysis. All the compounds have been evaluated for in vitro antibacterial, antifungal and antitubercular activities. The compounds exhibited weak antibacterial activity only at higher concentrations. Whereas, the antifungal activity results showed that few of the compounds were able to show moderate antifungal potency. The fungi used in the anti-microbial study were found to resistant to the other compounds. The antitubercuar activity results were encouranging as the few compounds were able to possess growth inhibiting properties against the mycobacterium tested i.e the compounds 7b, 7e and 7f possessed the MIC as low as 6.25µg/ml. Even though the compounds failed to possess anti-bacterial and antifungal activity, it is quite interesting to note that most of the compounds were found to be promising biological agents as antitubercular.
SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME …
Application of Chalcone in Synthesis ..
ThalesNano Nanotechology Inc - Publications
synthesis and biological activities of some new heterocycles containing nitrogen and sulphur html full text
Special Issues - Molecules - MDPI
Synthesis and in vitro biological evaluation of new pyrazole chalcones and heterocyclic diamides as ..
Molecules, an international, peer-reviewed Open Access journal.
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