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This phase of protein synthesis occurs when the ribosome reaches ..

High serum titers correlate well with the continuing presence of viral antigens in the liver.

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Plasma Protein Synthesis The liver is ..

AB - The purpose of the study was to examine whether an early decrease in protein synthesis rates occurred in any tissues after abdominal surgery in postprandial rats. Leucine-specific radioactivity in mixed protein and on tRNA was determined after continuous infusion of L-[3H]leucine. Synthesis rates of mixed protein were significantly decreased in the gastrocnemius muscle, but not in the jejunum, liver, or heart, of rats 1-2 hr after splenectomy and ovariectomy or after combining the groups that had various types of abdominal surgery. These results suggest that a very early decrease in the protein synthesis rate of the gastrocnemius muscle occurs after laparotomy.

C-reactive protein (CRP) a protein that is produced in the liver in response to inflammation

These series of organic acids circulate almost entirely in the localized blood flow between the intestines
and the liver (a.k.a. the Portal system). The flow is typically from the liver, into the bile duct system, then excretion into the intestines to aid digestion after a meal, to be re- absorbed into the portal system and recycled by the liver. Very little of the bile acids escape from the portal circulation system into the rest of the body. Leakage is considered abnormal and is a sure sign of a liver abnormality. This is one of the most sensitive tests available to diagnose liver disease. While the liver does actually manufacture this product, it has tremendous reserve capacity and can easily meet the bodies demand for bile acids despite severe disease. As a result of this reserve, the bile acid levels do not typically drop due to liver disease.

The peptides of the liver start protein synthesis in liver ..

After acute liver cell injury the Ito cells located in the necrotic areas of liver cells are markedly activitated for protein synthesis.

Perfect technique for visualizing the circulation of the liver, the bile duct system, the density of the liver tissue, the size of the liver. Ultrasound is highly beneficial in the diagnosis of liver disease. We recommend ultrasounding a liver when the liver enzymes tests are elevated over time, or the bile acids test is abnormal. The internal structure (called parenchyma) can be analyzed, and post-hepatic liver disease can be differentiated from hepatic liver disease. This can be very important because disease in the liver can often be diagnosed with a biopsy during the ultrasound. Post-hepatic liver disease cannot easily be diagnosed in this matter. Instead it is diagnosed and treated with an exploratory surgery (called a laparotomy).

Gamma Glutamyltransferase: GGT – This enzyme is has its highest concentration in the kidneys and pancreas, but it is also found in the liver and other organs. The major proportion of GGT in the serum seems to come from the liver. Elevations of GGT in disease seem to stem from new synthesis rather than leakage, therefore the changes seen due to disease are not spectacular. Large elevations of GGT are more commonly associated with pancreatitis and bile duct obstruction.

The major organ of plasma protein synthesis is the liver.

After acute liver cell injury the Ito cells located in the necrotic areas of liver cells are markedly activitated for protein synthesis.

A year ago at Jake’s annual checkup a senior panel was done and his Alk Phos level was elevated at 360. We had follow up 3 and 4 month follow up testing and it was unchanged. No other values were elevated at that time. We had our annual checkup last week and the results of his liver enzyme panel were not good. This time not only was the alk phos elevated to 662 but his ast and alt levels were also elevated, 289 and 687 respectfully. Obviously this was very disheartening as he is clinically asymptomatic. He shows no signs of any problems associated with these results. I immediately got on the internet and started reading to understand more about the potential for liver disease and found your foundation website. I wanted to tap into your experience and knowledge and hopefully get some feedback from you. We have an appointment Monday for xrays. My concern is this is the first time other enzyme levels have been elevated and could this be a fluke or testing error!! I found a round table discussion on this and it suggested repeating the test in 2 to 3 weeks to substantiate the results. I need to have this discussion with my vet and will do so Monday. Another concern is what I am feeding Jake. About six months ago I put him on a raw food diet (Primal). I tried to find info to see if this could be potentiating a liver problem. The only supplements he is on are kelp and a probiotic. I did have him on milk thistle when the initial alk phos level was elevated but only did this for two months. He has been on other nutritional supplements for skin and coat but I stopped those. I forgot he is also on organic coconut oil. There is a local health food store that specializes in dog nutrition and I have been following some of their recommendations for maximizing Jake’s health. Other than this Jake has had occasional ear , skin, and pad issues but for the most part had remained in good health. I might also add we exercise regularly, walking twice a day weather permitting. Needless to say I am quite concerned and any help you can provide would be greatly appreciated. I am considering requesting a consult to see an internal vet specialist. I have some other questions about further testing such as serum bile acid. I might also add that I am in medicine myself and knowing what I know about the human element heightens questions and poses trust issues in the care and treatment of Jake!!! I have had some unpleasant vet experiences and just changed vets so at this point my confidence level is being tested and it scares me… Thanks for listening and I look forward to hearing from you.

Specifically noting signs which may indicate liver disease. Periodic ascites, intolerance of a high protein diet, icterus, chronic weight loss, abnormally colored feces or urine, bleeding disorders, chronic illness, and all that has been mentioned above. Sometimes urinary crystals formed from the improperly metabolized proteins and amino acids may indicate liver disease.

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  • Protein synthesis occurs where in the cell ..

    Protein: Protein, highly complex substance that is present in all living organisms

  • Hepatitis C :: The Facts : The Liver - Protein Metabolism

    of need for synthesis of protein, providing about 50% of the liver energy ..

  • Protein Synthesis -Translation and Regulation

    Protein synthesis in liver and extra-hepatic tissues after partial hepatectomy

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Glossary | Linus Pauling Institute | Oregon State University

" The influence of “Amprolinsil” and “Brovitacoccid” on the protein synthesis function of the liver of turkeys affected by Eimeria and Histomonas "

Cholesterol: Synthesis, Metabolism, Regulation

The influence of “Amprolinsil” and “Brovitacoccid” on the protein synthesis function of the liver of turkeys affected by Eimeria and Histomonas

Human Physiology - Cell structure and function - EKU

A complete blood count to check for anemia and blood cell abnormalities. A CBC (complete blood
count) and BCP (biochemistry panel) should be run on every pet 8 years of age or more, especially if they have any of the symptoms of liver disease. The CBC might show a decrease in the number of red blood cells (RBC’s). This decrease in RBC’s is called anemia. The white blood cell count (WBC) might be elevated (leukocytosis), normal, or decreased (leukopenia), mostly depending on the cause of the liver problem and how long it has been present. A change in the WBC’s does not necessarily indicate there is a liver problem.

ALT | Canine Liver Disease Foundation

Alanine Aminotransferase: ALT – Liver specific. Cell damage will cause elevations of ALT due to leakage. The elevation of the enzyme correlates with the number of cells damaged. Falling levels of ALT may indicate recovery or may indicate a failing number of functional liver cells. Rapid increases in ALT may indicate an acute process, while slow increases may indicate bile duct obstruction.

Protein metabolism denotes the various biochemical ..

N2 - The purpose of the study was to examine whether an early decrease in protein synthesis rates occurred in any tissues after abdominal surgery in postprandial rats. Leucine-specific radioactivity in mixed protein and on tRNA was determined after continuous infusion of L-[3H]leucine. Synthesis rates of mixed protein were significantly decreased in the gastrocnemius muscle, but not in the jejunum, liver, or heart, of rats 1-2 hr after splenectomy and ovariectomy or after combining the groups that had various types of abdominal surgery. These results suggest that a very early decrease in the protein synthesis rate of the gastrocnemius muscle occurs after laparotomy.

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