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Harwood JL (ed) Plant lipid biosynthesis: ..

demonstrated that Niemann-Pick disease type C is a disease ofcholesterol metabolism ().

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Pentose Phosphate Pathway and Lipid Metabolism - plant …

demonstrated that nearly allphosphatidylserine and a minimum of 70% of phosphatidylethanolamine is on theinside surface of the human erythrocyte membrane, thus "presenting a strongevidence for an asymmetric arrangement of phospholipids" ().

First demonstration of an inhibition of sterol biosynthesis (HMG-CoA reductaseactivity) by oxygenated derivatives of cholesterol in cultured mammalian cells ().

For the first time, the existence of polyunsaturated fatty acids was reported inmarine bacteria ().

Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that ..

1961, 83, 3080) made the first total synthesis of arachidonic acid.

Imai J demonstrated that the oxidative desaturation of a saturated fatty acid (palmitic acid) is depressed in diabetic rats ().

Kennedy EP described the general pathways of the glycerolipid biosynthesis in animal cells ().

Bremer J et al.

Soybean Lipid Biosynthesis Pathway

Lipid metabolism, specially the pathways to fatty acids and TAG biosynthesis, is relatively well understood in plants, but poorly known in algae.

Cholesterol is an essential component of cell membranes and the precursor for the synthesis of steroid hormones and bile acids. The synthesis of this molecule occurs partially in a membranous world (especially the last steps), where the enzymes, substrates, and products involved tend to be extremely hydrophobic. The importance of cholesterol has increased in the past half-century because of its association with cardiovascular diseases, which are considered one of the leading causes of death worldwide. In light of the current need for new drugs capable of controlling the levels of cholesterol in the bloodstream, it is important to understand how cholesterol is synthesized in the organism and identify the main enzymes involved in this process. Taking this into account, this review presents a detailed description of several enzymes involved in the biosynthesis of cholesterol. In this regard, the structure and catalytic mechanism of the enzymes involved in cholesterol biosynthesis, from the initial two-carbon acetyl-CoA building block, will be reviewed and their current pharmacological importance discussed. We believe that this review may contribute to a deeper level of understanding of cholesterol metabolism and that it will serve as a useful resource for future studies of the cholesterol biosynthesis pathway.

To A, Joubès J, Barthole G, et al. (2012) WRINKLED transcription factors orchestrate tissue‐specific regulation of fatty acid biosynthesis in Arabidopsis. Plant Cell 24: 5007–5023.

MetaCyc superpathway of phospholipid biosynthesis II …

However, unlike higher plants where individual classes of lipids may be synthesized and localized in a specific cell, tissue or organ, the complete pathway, from carbon dioxide fixation to TAG synthesis and sequestration, takes place within a single algal cell.

Slocombe SP, Cornah J, Pinfield‐Wells H, et al. (2009) Oil accumulation in leaves directed by modification of fatty acid breakdown and lipid synthesis pathways. Plant Biotechnology Journal 7: 694–703.

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  • Pathway for lipid A biosynthesis in

    Abstract All plant cells produce fatty acids from acetyl-CoA by a common pathway localized in plastids

  • The phenolic compound biosynthesis pathway

    the extent to which proteins of the plant lipid synthesis pathway are ..

  • in a tryptophan -dependent auxin biosynthesis pathway

    Genome Modification Approaches to Metabolic Engineering of Lipid Biosynthesis

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of the sterol biosynthesis pathway is highly ..

This paper presents the current knowledge of the neutral storage lipids in plants and algae from fatty acid biosynthesis to TAG accumulation.

Copyright (c) 2011 Alexandro Cagliari, Rogerio Margis, Felipe dos Santos Maraschin, Andreia Carina Turchetto-Zolet, Guilherme Loss, Marcia Margis-Pinheiro

This work is licensed under a .

Biosynthesis of Plant-derived flavor compounds

Metabolism1.0 Global and overview maps1.1 Carbohydrate metabolism1.2 Energy metabolism1.3 Lipid metabolism1.4 Nucleotide metabolism1.5 Amino acid metabolism1.6 Metabolism of other amino acids1.7 Glycan biosynthesis and metabolism1.8 Metabolism of cofactors and vitamins1.9 Metabolism of terpenoids and polyketides1.10 Biosynthesis of other secondary metabolites1.11 Xenobiotics biodegradation and metabolism1.12 Chemical structure transformation maps

metabolic pathway for lipid biosynthesis plays a …

discovered the essentiality of thelong-chain polyunsaturated fatty acids (linoleic and linolenic acids) ().

Anderson RJ reported the presence of inositol in lipids of tubercle bacilli ().

First demonstration of the biosynthesis of vitamin A from

KEGG PATHWAY: Metabolic pathways - Reference pathway

Murphy DJ and Piffanelli P (1998) Fatty acid desaturases: structure mechanism and regulation. In: Harwood JL (ed) Plant Lipid Biosynthesis: Recent Advances of Agricultural Importance, pp. 95–1300. Cambridge: Cambridge University Press.

Lipid metabolism - What is Life HOME

of the antioxidant properties of tocopherols ().

First synthesis of linoleic acid ()

Kurz H used ethyl alcohol to derivatize fatty acids (FA ethyl esters) beforetheir analysis ().

First data on cholesterol and fatty acid metabolism after using an isotope of hydrogen(deuterium) in mice and chicks ().

Using deuterated acetate, Sonderhoff R et al. have shown that it serves asa precursor for sterols including ergosterol in yeast ().

Paul Karrer received the

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