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In the Federal Republic of Germany, PCP is synthesized by means of stepwise chlorination of phenols.
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Mild dysfunction of the liver has been reported among Soviet workers engaged in the production of Na-PCP (Vinogradova et al., 1973) including, for example, a reduced ability to synthesize protein.
Until 1984, Na-PCP was partly synthesized by means of the alkaline hydrolysis of hexachlorobenzene, but it is now produced by dissolving PCP flakes in sodium hydroxide solution.
Pentachlorophenol (EHC 71, 1987) – INCHEM
Adema & Vink (1981) found that the green alga Scenedesmus quadricauda had an EC50 for growth that was 87.5 times lower than that for Chlorella pyrenoidosa. The most sensitive algae were Ankistrodesmus falcatus and Microcystis sp., for which as little as 0.001 mg PCP/litre inhibited photosynthesis by an average of 21%, in semi-continuous cultures.
Industrial production18.104.22.168 Manufacturing processes PCP was first synthesized by Merz & Weith (1872) using a similar preparation method to that currently used during commercial production (Prager et al., 1923).
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PCP: PCP, hallucinogenic drug with anesthetic properties, having the chemical name 1-(1-phenylcyclohexyl)piperidine.
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