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@MISC{_parallelsynthesis, author = , title = {Parallel Synthesis of Large Combinational Circuits for FPGAs}, year = }

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WHAT IS PARALLEL SYNTHESIS CHEMISTRY

AB - We report here the first rapid parallel production of bioactive folded cyclotides by using Fmoc-based solid-phase peptide synthesis in combination with a "tea-bag" approach. Using this approach, we efficiently synthesized 15 analogues of the CXCR4 antagonist cyclotide MCo-CVX-5c. Cyclotides were synthesized in a single-pot, cyclization/folding reaction in the presence of reduced glutathione. Natively folded cyclotides were quickly purified from the cyclization/folding crude mixture by activated thiol Sepharose-based chromatography. The different folded cyclotide analogues were then tested for their ability to inhibit the CXCR4 receptor in a cell-based assay. The results indicated that this approach can be used for the efficient chemical synthesis of libraries of cyclotides with improved biological properties that can be easily interfaced with solution or cell-based assays for rapid screening.

T1 - Rapid parallel synthesis of bioactive folded cyclotides by using a tea-bag approach

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Sophas Automated Parallel Synthesis

Parallel synthesis of benzoxazoles via microwave …

Since 2000 Parallel Synthesis Technologies, Inc. has provided a variety of tools, devices and technologies including micromachined silicon tools , devices and substrates for protein crystallization and optical encoding technology for assay multiplexing

The unit enables organic chemists to more quickly incorporate parallel synthesis techniques into their daily workflow.FirstMate, says Agronaut, is the simplest way to synthesize a small series of compounds in parallel without sacrificing the flexibility and robustness of traditional benchtop chemistry."Although many chemists are feeling pressure to work faster, they are resistant to adopting a new technique if it might limit their synthesis options," says Argonaut concept design VP Terry Long.

Parallel Synthesis of Ureas and Carbamates from Amines …

"We knew we had to design a simple set of modules that would deliver the productivity advantages of performing reactions in parallel, combined with both the wide range of chemistry capability and hands-on control of synthesis in traditional glassware."FirstMate's features, says Long, will promote broader use of parallel synthesis.

Combined with the local support of parallel synthesis, the jitter enables intuitive user controls including multiscale randomness, spatial modulation over both exemplar and output, feature drag-and-drop, and periodicity constraints.

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    The parallel synthesis of small focused libraries has become an important strategy for the follow-up of screening hits

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Solid-Phase Parallel Synthesis of Phosphite Ligands

A combinatorial library of oxazolines and thiazolines was synthesized in moderate to excellent yields using a newly developed methodology. Free carboxylic acids were directly condensed with amino alcohols and aminothiols in the presence of 3-nitrophenylboronic acid as a dehydration catalyst. The library synthesis illustrates the scope of this process: After traditional reaction optimization, a total of 17 oxazolines and 6 thiazolines were successfully prepared in a 24-reaction setup in a Radleys GreenHouse parallel synthesizer. The yields of the parallel reactions ranged from moderate to excellent, depending largely on carboxylate reactivity and functionalization, and generally exceeded those of the traditional reaction setup. The target compounds were isolated in high purities (average purity is 96% according to GC analysis) after passing reaction mixtures through short PrepSep SPE Florisil cartridges.

Parallel synthesis of N -biaryl quinolone ..

For high-throughput parallel synthesis, a special 96-well reactor system has been developed using glass tubes of 1.1ml volume or a solid glass block with 96 cavities of 1.8ml volume. Contamination and unwanted atmospheric reactions are prevented by multiple layers of pierceable septa above the reactors which act as gas barriers as well as pressure vents.

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T1 - Parallel Synthesis of Oxazolines and Thiazolines by Tandem Condensation - Cyclodehydration of Carboxylic Acids with Amino Alcohols and Aminothiols

FLEX ISYNTH - Automated Parallel Multistep Synthesis - …

N2 - A combinatorial library of oxazolines and thiazolines was synthesized in moderate to excellent yields using a newly developed methodology. Free carboxylic acids were directly condensed with amino alcohols and aminothiols in the presence of 3-nitrophenylboronic acid as a dehydration catalyst. The library synthesis illustrates the scope of this process: After traditional reaction optimization, a total of 17 oxazolines and 6 thiazolines were successfully prepared in a 24-reaction setup in a Radleys GreenHouse parallel synthesizer. The yields of the parallel reactions ranged from moderate to excellent, depending largely on carboxylate reactivity and functionalization, and generally exceeded those of the traditional reaction setup. The target compounds were isolated in high purities (average purity is 96% according to GC analysis) after passing reaction mixtures through short PrepSep SPE Florisil cartridges.

Argonaut Launches Parallel Organic Synthesis System

AB - A combinatorial library of oxazolines and thiazolines was synthesized in moderate to excellent yields using a newly developed methodology. Free carboxylic acids were directly condensed with amino alcohols and aminothiols in the presence of 3-nitrophenylboronic acid as a dehydration catalyst. The library synthesis illustrates the scope of this process: After traditional reaction optimization, a total of 17 oxazolines and 6 thiazolines were successfully prepared in a 24-reaction setup in a Radleys GreenHouse parallel synthesizer. The yields of the parallel reactions ranged from moderate to excellent, depending largely on carboxylate reactivity and functionalization, and generally exceeded those of the traditional reaction setup. The target compounds were isolated in high purities (average purity is 96% according to GC analysis) after passing reaction mixtures through short PrepSep SPE Florisil cartridges.

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