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Scientific collaboration in Poland and abroad
List of the research projects realized in the collaboration with the centers abroad under the bilateral and multicenter agreements.
Two research groups have tested intraneural stimulation using silicon-substrate arrays. Zappia and colleagues (Zappia et al. ) tested a five-electrode single-shank thin-film array similar to that used in the present study. They implanted the stimulating array for periods of 5 weeks in guinea pigs, using a lateral approach through the cochlear basal turn. Histological study showed that the implants were tolerated well by the cochlear tissue, with damage in most cases restricted to the loss of spiral-ganglion cells near the implanted silicon shank. Functional responses to biphasic electrical pulses were monitored as middle-latency responses. Thresholds ranged from 1 to 4 nC, somewhat higher than that obtained in the present study. Hillman and colleagues (Hillman et al. ) tested in cats a silicon-substrate device consisting of 6 to 19 1-mm-long silicon shanks, spaced on a 400-μm grid, with one stimulating site at the tip of each shank. The median EABR threshold was 1.1 nC.
Units collaborating with the Institute include:
Ongoing studies will assess safety and efficacy of long-term stimulation in chronically implanted animals prior to eventual human trials.
Experimental approaches used in the lab include human and animal psychophysics, and single-unit neurophysiology in anesthetized and awake/behaving animals.
In exclusive collaboration with Charles University in Prague, one of the best and oldest universities in Europe in the field of medical science.
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Spatial tuning curves elicited by individual and simultaneous monopolar stimulation of two scala tympani electrodes. The left ordinate axis plots recording depth in the ICC relative to the most superficial recording site; corresponding CFs are plotted on the right ordinate. The abscissa plots the current level of single electrical pulses. (A) and (C) Responses to monopolar stimulation of scala tympani electrodes 3 and 8, respectively, stimulated individually in monopolar configuration. Electrode 8 was centered in the scala tympani 3.75 mm more apical than electrode 3. (B) Activity elicited by simultaneous stimulation of the two electrodes. Stimulus currents on the two electrodes were varied in parallel; upper and lower rows of abscissa labels refer to currents presented to the electrodes represented in panels (A) and (C), respectively. The current ranges used in the simultaneous condition (indicated with black bars in panels (A) and (C)) were entirely below the thresholds for activation with either electrode alone. FSDR is defined in the text. Cat0509.
Audiology is a fast evolving discipline. Plenty of researches have been undertaken worldwide in the past decades in areas including, but are not limited to, electrophysiologic measurements of neural function, hearing conservation programs, auditory implants, vestibular rehabilitation therapy, tinnitus, speech perception, auditory processing, psychoacoustics, hearing aid design, and the psychosocial consequences of hearing loss. The Department of Otorhinolaryngology, Head and Neck Surgery is a local leader in the field of auditory implants. It was the key research centre for cochlear implant in Asia Pacific region, and performed the first auditory brainstem implant and the first bone-anchored hearing aid implantation in irradiated nasopharyngeal cancer patient in Asia.
Auditory Prosthesis Lab - Ohio University
The Pfingst Laboratories at the Kresge Hearing Research ..
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Laboratory of Neural Prosthetic Research – at the …
Welcome to the Laboratory of Neural Prosthetic Research
The Laboratory of Neuroprosthetic Research is a team-based ..
Topography of cochlear nerve and nucleus in the cat (reprinted from Arnesen and Osen, with permission from the publisher). The projections from the apical, middle, and basal turns to the cochlear nucleus are indicated with lines varying in thickness. The two cross sections (lower right, labeled I and II) show the approximate locations within the nerve of fibers from various cochlear turns. Medium, clear, and dense shading indicate fibers from the basal, middle, and apical turns, respectively. The line in cross section II indicates a typical placement of the stimulating array, estimated on the basis of frequency-specific responses recorded in the ICC and post-mortem dissections. Abbreviations: AVCN: anterior ventral cochlear nucleus; DCN: dorsal cochlear nucleus; CNR: cochlear nerve root; GB: glial border; LF: low frequency; HF: high frequency.
The Auditory Physiology Laboratory - UI Health Care
Dr. Daim’s research team and the project partner (Value Management Strategies, Inc. VMS) are working together to develop a guide that identifies available and proposes additional tools and techniques to foster useable and improved practices for key stakeholders. The research aims to combine some existing value management tools and processes for improving transportation project outcomes conducting under the National Cooperative Highway Research Program (NCHRP) in U.S.
Miller Laboratory Collaborators
Stimulus presentation and data acquisition used System 3 equipment from Tucker-Davis Technologies (TDT; Alachua, FL, USA) and custom software running in MATLAB (The MathWorks, Natick, MA, USA). The electrical pulses were generated by custom optically isolated 8- or 16-channel current sources controlled by 16-bit digital-to-analog converters (TDT RX8). The 8-channel current source used for the scala-tympani stimulation had a maximum output of 3 mA. The 16-channel current source used for the intraneural stimulation had a maximum output of 1 mA.
Auditory Prosthesis Psychophysics and Perception Lab
Spatial tuning curves elicited by intraneural stimulation. Each panel corresponds to one stimulus site, labeled according to depth relative to the most proximal (i.e., superficial) stimulation site. Illustrated examples are from 8 of the 16 available sites on the stimulating array. These spatial tuning curves appear somewhat patchier than those for acoustic stimulation in Figure , largely because these data for intraneural stimulation were collected at 32 stimulus levels in 1-dB steps, whereas the data for acoustic stimulation were collected at only 13 levels in 5-dB steps, necessitating somewhat greater interpolation in the contour plots. Cat0509.
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