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at least in part, for the airway hyperresponsiveness and asthmatic diathesis observed in many of these patients

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Allergy articles: The New England Journal of Medicine

Asthma used to be thought of as an entirely reversible disorder. As a consequence, our therapeutic approach to asthma has focused on symptomatic control through the alleviation of bronchospasm and the reduction of airway inflammation. It is now known, however, that this optimistic picture of the natural history of asthma is not entirely complete. A number of studies have demonstrated that asthmatics, as a group, experience an accelerated rate of respiratory functional deterioration (, ). This is nicely illustrated in a recent study of 17,506 people followed over a 15-year period in the Copenhagen Heart Study. In this population, the 1,095 patients with self-reported asthma experienced a greater decline in airway function (forced expiratory volume in 1 second [FEV1]) than did controls (38 mL per year vs. 22 mL per year), and the greatest rates of decline were experienced by smokers with asthma (). Patient-to-patient variability has also been noted, with some patients acquiring a physiologic state characterized by irreversible or partially reversible airway obstruction, and others manifesting incomplete β-agonist responses and persistent airways hyperresponsiveness (AHR) even after prolonged corticosteroid therapy. The pathologic correlates and pathogenetic mechanisms responsible for these findings are incompletely understood. Recent attention has, however, been directed at the structural changes — collectively referred to as airway remodeling — in the asthmatic and normal airway. This is based on the belief that these changes are responsible, in a cause-and-effect fashion, for these adverse outcomes and for other manifestations of the asthmatic diathesis. The change that this represents in our concept of the pathogenesis of asthma and the features and pathogenesis of asthmatic airway remodeling is reviewed below.

Online Medical Dictionary and glossary with medical definitions, a listing.

An atopic diathesis, i.e., a genetic predisposition toward the production of IgE antibodies in response to (for example) pollen, house dust mites, fungi, or animal-derived proteins, is the most important risk factor for bronchial asthma.

Asthma - Cleveland Clinic Center for Continuing Education

coordinate the presence of airways inflammation and therefore may prove to be critical to the development of the asthmatic diathesis.

AB - Bronchial asthma is a chronic condition that is on the increase in adolescents as it is among other age groups; often under-diagnosed it prevalently affects males and is 10% sustained by an allergic diathesis. Adolescence, with its peculiarities and characteristic psychological and physical changes affects the clinical expression of asthma and above all requires particular diagnostic and therapeutic attention from the treating paediatrician. The physician should act as a direct, credible interlocutor of the adolescent. Regular sporting activity appropriate to the subject's age and asthmatic condition, and under close medical supervision, must be recommended in the asthmatic adolescent. Bronchial asthma in adolescence often presents as asthma due to physical effort. The onset of asthma must not represent an impediment to regular physical activity; adequate management strategies are however necessary (so as to prevent the symptom occurring after effort). These strategies range from the choice of type of training (environment and work loads) to pharmacological prevention measures. The asthmatic adolescent may also perform physical activity at competitive level although in this case special attention must be paid to the choice of drugs so as to avoid running into problems of disqualification due to doping.

Two adolescent cases were diagnosed as exercise-induced anaphylaxis (EIA) with urticaria, dyspnea and loss of consciousness after exercise.
A thirteen year old boy had 5 episodes of generalised urticaria, dyspnea and confusion after running since 11 years of age and responded mildly to bicycle ergometer. A sixteen year old asthmatic girl had several episodes of swelling on eyelids, papular rash on extremities within 2 hours after eating and followed by generalised urticaria, dyspnea and confusion after running since 14 years of age, but didn't respond to bicycle ergometer. Both cases showed typical sympotoms of EIA in adolescent age with high serum IgE and atopic diathesis.

Health Topics A-Z - Health and Mediacal Counselling …

in a cause-and-effect fashion, for these adverse outcomes and for other manifestations of the asthmatic diathesis.

The first Perspective in this series, by Gern, Lemanske and Busse, deals with the early life origins of the asthmatic diathesis, and the second article, by Oettgen and Geha, highlights recent insights into the importance of IgE and new anti-IgE-based therapies in atopy and the asthmatic response. The third article by Ray and Cohn highlights the large body of data that has now been generated regarding the cellular and molecular events that regulate and the effector functions of Th2 inflammatory responses, and the fourth article by Lukacs and colleagues describes the organized chemokine network that is involved in the generation of airway inflammation. The last article in the series by Elias et al. deals with the structural changes and the concept of asthmatic airway remodeling, highlighting both our level of knowledge and the challenges for the future.

Asthma continues to challenge physicians and scientists. After declining for years, the prevalence, morbidity and mortality of asthma have increased over the last two decades. In keeping with the importance of this “epidemic,” significant attention has been focused on the pathogenesis of this disorder. These investigations have revised our concepts of the abnormalities that underlie the asthmatic diathesis and our understanding of crucial aspects of its natural history. They have also provided exciting insights into the cellular and molecular events that regulate airway inflammation and inflammation in other tissues. It is clear from these studies that a genetic predisposition plus an appropriate life event(s) conspire to generate the asthmatic diathesis and that often early life (and possibly in utero) events play a crucial role in disease pathogenesis. It is also clear that inflammation is the cornerstone of asthma and that, in the majority of cases, Th2 dominated tissue responses are responsible for this disorder. Recently, the non-inflammatory structural alterations in the asthmatic airway have received renewed attention and the roles these structural changes may play in generating symptomatology and altering natural history have begun to be elucidated.

The Allergy page contains articles and information from the New England Journal of Medicine.
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  • Pfizer Consumer Healthcare - Medicines

    Pathology

  • Colchicum | National Center for Homeopathy

    Bronchial Asthma Online Medical Reference - including diagnostic evaluation and experimental therapies

  • Melanthacae of the Liliaceæ

    Authored by Mani S

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2018 ICD-10-CM Codes J45*: Asthma

Melanthacae of the Liliaceæ.
Tincture of the bulb dug in spring.

Clinical.
Appendicitis.
Asthma.
Cataract.
Cholera.
Colic.
Cough.
Cramp.
Debility.
Diabetes.
Diarrhea.
Dropsy.
Dysentery.
Eye, affections of.
Feet, painful.
Gout.
Heart, affections of.
Ileus.
Intermittent fever.
Intestinal catarrh.
Lumbago.
Myalgia.
Nephritis (rheumatic and gouty).
Pericarditis.
Proctalgia.
Prostatitis, Rectum, prolapse of.
Rheumatism.
Stiff-neck.
Tongue, sensibility lost.
Typhlitis.
Typhoid fever.

Characteristics.
Colchicum is best known as a remedy in gout and rheumatism, and the provings show its specific relation thereto.
It acts on muscles, bones, and joints.
It causes extreme relaxation of the muscular system, the head falls forward on the chest, or falls back when the patient is raised from the pillow, arms fall helpless by the side.
Stitching, jerking, drawing pains in muscles, periosteum, and joints.
Extreme disinclination to move, worse from motion.
Mind befogged, but answers correctly.
Absence of apprehension, no fear of death.
Results of getting wet and getting chilled, changes to damp weather, autumn dysentery, spring rheumatism.
(The flowers of the plant appear in autumn, the leaves not till the following spring.) It corresponds to the gouty constitution, leucophlegmatic and melancholic temperament, venous constitutions, uric acid diathesis, the sediment being pale yellow and rather like fine flour than sand.
Also, urine black as ink, urine loaded with albumen and casts.
There is the irritability and aversion to touch so common in gout, pain in small joints, and especially the great toes.
The stomach is acutely disordered, nausea and vomiting.
"Nausea at thought, sight, or smell of food, especially of cooking," is a characteristic symptom.
(Nash records a striking cure by Colch.

Definition of Diathesis - MedicineNet

1. Rubrics related to constitutional diathesis include; Hysterical, constitutions; Hemorrhagic, constitutions; Lymphatic, constitutions; Venous, constitutions; Plethoric, constitutions; Rheumatic, constitutions; Scrofulous, constitution; Paralytic, constitutions; Gouty, constitutions; Tubercular, constitutions; Asthmatic constitutions; and their similar remedies.

Read medical definition of Diathesis ..

Bronchial asthma is a chronic condition that is on the increase in adolescents as it is among other age groups; often under-diagnosed it prevalently affects males and is 10% sustained by an allergic diathesis. Adolescence, with its peculiarities and characteristic psychological and physical changes affects the clinical expression of asthma and above all requires particular diagnostic and therapeutic attention from the treating paediatrician. The physician should act as a direct, credible interlocutor of the adolescent. Regular sporting activity appropriate to the subject's age and asthmatic condition, and under close medical supervision, must be recommended in the asthmatic adolescent. Bronchial asthma in adolescence often presents as asthma due to physical effort. The onset of asthma must not represent an impediment to regular physical activity; adequate management strategies are however necessary (so as to prevent the symptom occurring after effort). These strategies range from the choice of type of training (environment and work loads) to pharmacological prevention measures. The asthmatic adolescent may also perform physical activity at competitive level although in this case special attention must be paid to the choice of drugs so as to avoid running into problems of disqualification due to doping.

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