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Inhibition of nucleic acid synthesis, ..

Some antibiotics inhibit the enzymes involved in bacterial cell wall synthesis, protein synthesis or nucleic acid synthesis

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Inhibiting Nucleic acid synthesis; ..

Mutants of Escherichia coli resistant to the antibiotic clorobiocin are also coumermycin resistant, and the mutation to resistance in at least one mutant was mapped near gyrB. We conclude, therefore, that clorobiocin inhibits deoxyribonucleic acid gyrase, and the drug was used to probe the role of this enzyme in vivo. Deozyribonucleic acid synthesis was preferentially inhibited but not completely blocked by the antibiotic. Transcription and cell division were also markedly affected. However, unlike other inhibitors of deoxyribonucleic acid synthesis, clorobiocin failed to induce the synthesis of protein X, the recA gene product. In mutants resistant to clorobiocin the replication velocity was unaffected, but initiation of deoxyribonucleic acid synthesis appeared to be delayed. We conclude that deoxyribonucleic acid gyrase, and hence the supercoiled structure of the chromosome, is important for transcription, normal initiation of deoxyribonucleic acid replication, and cell division. The possible role of deoxyribonucleic acid gyrase in the elongation of replication forks is also discussed.

Antibiotics: Protein Synthesis, Nucleic Acid Synthesis …

Because these two drugs act on sequential steps of a single pathway their co-administration results in synergistic inhibition of bacterial nucleic acid and amino acid synthesis.


This Concept Map, created with IHMC CmapTools, has information related to: Answers_Antibiotic_CW_CM_NA, Antibiotic/chemical agent inhibits normal nucleic acid replication.

Most antibiotics in clinicalusage are directedagainst bacterial cell wall synthesis, bacterial protein synthesis, orbacterialnucleic acid synthesis, which are unique in some ways tobacteria. For example, the beta lactam antibiotics (penicillin and its relatives)inhibit peptidoglycan synthesis in the cell wall.

Antibiotics as Inhibitors of Nucleic Acid and Protein Synthesis.

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