Inhibition of nucleic acid synthesis, ..
Some antibiotics inhibit the enzymes involved in bacterial cell wall synthesis, protein synthesis or nucleic acid synthesis
Inhibiting Nucleic acid synthesis; ..
Mutants of Escherichia coli resistant to the antibiotic clorobiocin are also coumermycin resistant, and the mutation to resistance in at least one mutant was mapped near gyrB. We conclude, therefore, that clorobiocin inhibits deoxyribonucleic acid gyrase, and the drug was used to probe the role of this enzyme in vivo. Deozyribonucleic acid synthesis was preferentially inhibited but not completely blocked by the antibiotic. Transcription and cell division were also markedly affected. However, unlike other inhibitors of deoxyribonucleic acid synthesis, clorobiocin failed to induce the synthesis of protein X, the recA gene product. In mutants resistant to clorobiocin the replication velocity was unaffected, but initiation of deoxyribonucleic acid synthesis appeared to be delayed. We conclude that deoxyribonucleic acid gyrase, and hence the supercoiled structure of the chromosome, is important for transcription, normal initiation of deoxyribonucleic acid replication, and cell division. The possible role of deoxyribonucleic acid gyrase in the elongation of replication forks is also discussed.
Because these two drugs act on sequential steps of a single pathway their co-administration results in synergistic inhibition of bacterial nucleic acid and amino acid synthesis.
This Concept Map, created with IHMC CmapTools, has information related to: Answers_Antibiotic_CW_CM_NA, Antibiotic/chemical agent inhibits normal nucleic acid replication.
Most antibiotics in clinicalusage are directedagainst bacterial cell wall synthesis, bacterial protein synthesis, orbacterialnucleic acid synthesis, which are unique in some ways tobacteria. For example, the beta lactam antibiotics (penicillin and its relatives)inhibit peptidoglycan synthesis in the cell wall.
Antibiotics as Inhibitors of Nucleic Acid and Protein Synthesis.
inhibiting nucleic acid synthesis
Nucleic acid synthesis inhibitors
20/12/2016 · Inhibition of nucleic acid biosynthesis in procaryotic and eucaryotic cells by ..
inhibits nucleic acid synthesis
Antibiotics: Protein Synthesis, Nucleic Acid Synthesis and Metabolism - PowerPoint PPT Presentation
inhibition of bacterial nucleic acid and amino acid synthesis.
29/08/2017 · Inhibition of deoxyribonucleic acid gyrase: effects on nucleic acid synthesis and ..
"I have always been impressed by the quick turnaround and your thoroughness. Easily the most professional essay writing service on the web."
"Your assistance and the first class service is much appreciated. My essay reads so well and without your help I'm sure I would have been marked down again on grammar and syntax."
"Thanks again for your excellent work with my assignments. No doubts you're true experts at what you do and very approachable."
"Very professional, cheap and friendly service. Thanks for writing two important essays for me, I wouldn't have written it myself because of the tight deadline."
"Thanks for your cautious eye, attention to detail and overall superb service. Thanks to you, now I am confident that I can submit my term paper on time."
"Thank you for the GREAT work you have done. Just wanted to tell that I'm very happy with my essay and will get back with more assignments soon."